Historic first: Pfizer agrees to lower prescription drug prices

Daily News Article   —   Posted on October 1, 2025

(by Lisa Hornung, UPI) — President Donald Trump announced Tuesday that he has secured a deal with drugmaker Pfizer to lower its prescription prices. Trump made the announcement alongside several health officials, including HHS Secretary Bobby Kennedy Jr., Dr. Mehmet Oz, Administrator for the Centers for Medicare & Medicaid Services (CMS), Dr. Marty Makary, FDA Commissioner, and Albert Bourla, CEO of Pfizer.

The White House also announced a new direct-to-consumer website to sell prescription drugs at discounted rates, calling it TrumpRX, the administration said in a statement. The president didn’t elaborate on how it will work, [and the launch date for the website has not yet been given].

“This is a really big announcement,” Trump said. “This is something that most people said was not doable.” He said more deals with other drugmakers would follow.

Trump signed an executive order in May to get “most-favored nation status” (MFN) with pharmaceutical companies, and the administration has been negotiating with drug companies since then.

“Starting today, the United States will no longer subsidize the healthcare of foreign countries, which is what we were doing,” Trump said at the time. “They paid a small fraction for the same [prescription] drug we pay many, many times more for.”

[The discounts Americans will receive match the lowest prices that developed countries like the UK, France, and Germany pay for the same medicines. Of note: insulin and epinephrine prices for low-income or uninsured patients are sharply reduced under these policies].

The MFN status means that “foreign nations [developed nations] can no longer use price controls to freeride on American innovation by guaranteeing MFN prices on all new innovative medicines Pfizer brings to market,” a Sept. 30 White House fact sheet said. “The agreement requires Pfizer to offer medicines at a deep discount off the list price when selling directly to American patients.”

The fact sheet lists three examples of Pfizer’s medications and their discounts:

  • Eucrisa, a topical ointment for atopic dermatitis, will be made available at an 80% discount to patients purchasing directly. Eucrisa retails at $856.80, according to Amazon Pharmacy, bringing it down to $171.36.
  • Xeljanz, an oral medication for rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, will be available at a 40% discount. Xeljanz retails at $6,559.20 per month. With a 40% discount, the price will be $3,935.52 per month.
  • Zavzpret, a treatment for migraines, will be sold at a 50% discount. Zavzpret retails at $1,223.64, making it $611.82.

“In case after case, our citizens pay massively higher prices than other nations pay for the same exact pill, from the same factory, effectively subsidizing socialism [abroad] with skyrocketing prices at home,” Trump said in a statement. “So we would spend tremendous amounts of money in order to provide inexpensive drugs to another country. And when I say the price is different, you can see some examples where the price is beyond anything — four times, five times different.”

In July, Trump sent letters to pharmaceutical companies asking them to lower prices within 60 days, the Washington Post reported [and listing steps they should take to bring U.S. prices down to equal the lower prices European countries pay.] …

Pfizer also said it will announce an $70 billion investment in research and development as well as domestic manufacturing, the White House said.

Abridged from a UPI report published on September 30. Reprinted here for educational purposes only. May not be reproduced on other websites without permission.



Background

President Trump's RX plan is a major initiative announced in September 2025 aimed at lowering prescription drug prices for Americans by partnering with Pfizer (with the expectation other drug companies will partner also) and launching a direct-to-consumer purchasing site called TrumpRx.

The plan is expected to save lots of money for everyday people who need prescription medications regularly.

Key Components

  • The TrumpRx website will allow Americans to buy many Pfizer medications and some other brands at an average discount of 50%, paying cash directly instead of going through insurance.
  • Pfizer will supply almost all its drugs to Medicaid at prices matching those offered in Europe and other comparable countries, targeting low-income Americans.
  • Newly launched medicines in the U.S. by Pfizer will also be offered at these discounted rates.
  • Pfizer receives three years of exemption from national security-related tariffs in exchange for cutting prices and investing in domestic manufacturing in the U.S..
  • The plan incorporates Trump’s “Most-Favored-Nation” policy, which compels pharmaceutical companies to offer U.S. consumers the same or better prices than those given to foreign countries. (from a Perplexity AI serach)

The Trump RX plan aims to end Americans’ subsidizing of foreign drug discounts, making U.S. drug prices more fair compared to those paid abroad and bringing relief from inflated prices driven by global “free riding” on U.S. pharmaceutical innovation. (WhiteHouse.gov)